Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses
Identifieur interne : 000C72 ( Main/Exploration ); précédent : 000C71; suivant : 000C73Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses
Auteurs : Matthew R. Sandbulte [États-Unis] ; Kim B. Westgeest [Pays-Bas] ; Jin Gao [États-Unis] ; Xiyan Xu [États-Unis] ; Alexander I. Klimov [États-Unis] ; Colin A. Russell [Royaume-Uni, États-Unis] ; David F. Burke [Royaume-Uni] ; Derek J. Smith [Pays-Bas, Royaume-Uni, États-Unis] ; Ron A. M. Fouchier [Pays-Bas] ; Maryna C. Eichelberger [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2011.
Abstract
Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers and antigenic cartography. As previously shown for HA, genetic changes in NA did not always lead to an antigenic change. The noncontinuous pattern of NA drift did not correspond closely with HA drift in either subtype. Although NA drift was demonstrated using ferret sera, we show that these changes also impact recognition by NA-inhibiting antibodies in human sera. Remarkably, a single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains. These data underscore the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA.
Url:
DOI: 10.1073/pnas.1113801108
PubMed: 22143798
PubMed Central: 3251064
Affiliations:
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Sandbulte</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Westgeest, Kim B" sort="Westgeest, Kim B" uniqKey="Westgeest K" first="Kim B." last="Westgeest">Kim B. Westgeest</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name><affiliation wicri:level="2"><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I." last="Klimov">Alexander I. Klimov</name><affiliation wicri:level="2"><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Burke, David F" sort="Burke, David F" uniqKey="Burke D" first="David F." last="Burke">David F. Burke</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers and antigenic cartography. As previously shown for HA, genetic changes in NA did not always lead to an antigenic change. The noncontinuous pattern of NA drift did not correspond closely with HA drift in either subtype. Although NA drift was demonstrated using ferret sera, we show that these changes also impact recognition by NA-inhibiting antibodies in human sera. Remarkably, a single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains. These data underscore the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA.</p></div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Sandbulte, Matthew R" sort="Sandbulte, Matthew R" uniqKey="Sandbulte M" first="Matthew R." last="Sandbulte">Matthew R. Sandbulte</name></region><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I." last="Klimov">Alexander I. Klimov</name><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name></country><country name="Pays-Bas"><noRegion><name sortKey="Westgeest, Kim B" sort="Westgeest, Kim B" uniqKey="Westgeest K" first="Kim B." last="Westgeest">Kim B. Westgeest</name></noRegion><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name></noRegion><name sortKey="Burke, David F" sort="Burke, David F" uniqKey="Burke D" first="David F." last="Burke">David F. Burke</name><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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